產(chǎn)品描述
Recombinant Human Matrix Metalloproteinase-9 is produced by our Mammalian expression system and the target gene encoding Ala19-Asp707 is expressed with a 6His tag at the C-terminus.The proenzyme needs to be activated by APMA for an activated form.
蛋白編號
AAH06093.1
產(chǎn)品別稱
Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; MMP9
分子量
77.4 KDa
表觀分子量
90 KDa, reducing conditions
劑型描述
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 2mM CaCl2, 150mM NaCl, 0.05% Brij35(w/v), pH 7.5.
內(nèi)毒素
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
純度-SDS-PAGE
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
保存條件
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
運(yùn)輸條件
The product is shipped on ice packs.
Upon receipt, store it immediately at the temperature listed below.
產(chǎn)品背景
Matrix metallopeptidase 9 (MMP-9) is an enzyme encoded by the MMP9 gene. This protein, which is produced by normal alveolar macrophages and granulocytes, can be activated by 4-aminophenylmercuric acetate and phorbol ester and up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. MMP-9 is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, angiogenesis, bone development, wound healing, cell migration, learning and memory, as well as in pathological processes, such as arthritis, intracerebral hemorrhage, and metastasis.